LPS goes non-canonical
نویسندگان
چکیده
منابع مشابه
Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity.
Lipopolysaccharide (LPS) is the major component of Gram-negative bacteria cell wall. In innate immunity, extracellular LPS is recognized by Toll-like receptor 4 to stimulate cytokine transcription. Recent studies suggest a 'non-canonical inflammasome' that senses cytoplasmic LPS and activates caspase-11 in mouse macrophages. Unexpectedly, biochemical studies reveal that caspase-11 and its human...
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ژورنال
عنوان ژورنال: Nature Reviews Microbiology
سال: 2013
ISSN: 1740-1526,1740-1534
DOI: 10.1038/nrmicro3106